This study aimed to explain some of the underlying problems were discussed, as follows: (1) identify the performance of District Health Clinics Tamalate, especially Jongaya and Barombong health center in order to improve the quality of health services; (2) to describes the optimization of the health center's empowerment in accordance with applicable law; (3) determining the level of empowerment of the health center in the realization of the tasks and functions carried in improving the quality of health services; (4) to evaluate the health center's empowerment program efficiently and effectively in improving public health in Tamalate District Makassar City. The method used in this research was descriptive with data collecting technique observation, interviews, and Focused Group Discussion (FGD) were carried out with the involvement of doctors, paramedics (midwives, nurse, nurse practitioner), the government and citizens. Data analysis technique used was qualitative to describe comprehensively optimizing the empowerment of PHC in improving the quality of health services in accordance with government standards.The results of this study showed that, in health centers as an institutionalized health care unit had significant authority in creating innovative health care models in cedar base. That requires commitment and a willingness to improve / leveling the quality and quantity of health services by revitalizing basic health care, expanding the network effectively and efficiently in the health centers, increasing the number and quality of health personnel, the establishment of service standards minimum health, health system performance are comprehensive, and improving information systems at all levels of government. PHC had three functions, namely: (1) as the central driver of health oriented development; (2) the center of community empowerment, and (3) the family in the development of health and health care centers were first rate. The third function of this health center is not only a technical issue but also how medical skills of human resources capable of organizing the social capital in the community. The function and role of health centers as health agencies to reach people in the smallest area requires a strategy in terms of organizing society to be involved in the implementation of health independently.