Infertility is a sad experience to have. Infertility among married couples in Onitsha Education Zone of Anambra State has been traced to emanate from infectious diseases mainly sexually transmitted infections. Complications from previous surgical operations, closure of cervical holes, inability to ovulate, tubal blockage, abnormalities in male reproductive organs, poor sperm production and deposition. Married couples with infertility problem suffer psychological and emotional stress like anger, fear, anxiety, frustration and depression. They also suffer some social effects like stigmatization and rejection. This study is aimed at ascertaining the perception of infertility and associated factors among married women and men in Onitsha Education Zone of Anambra State. A sample of 520 women and 400 men used for the study were selected through proportionate stratified random sampling techniques. To ensure effective representation, the researcher sampled married women and men according to the three Local Government Areas that make up Onitsha Education Zone of Anambra State. The instrument used for data collection was a self-structured questionnaire validated for face and content validity by two experts from the Department of Measure and Evaluation Chukwuemeka Odumegwu Ojukwu University, Igbariam Campus. The research used a trial test and a Pearson product movement correlation technique to determine the reliability at 0.85 and 0.82 for married women and men respectively. From findings of the study the researcher hereby recommends, practice of personal hygiene, treatment of infertility problems by specialist doctors, health education given to members of Onitsha Education Zone of Anambra State and the general public about infertility and its associated factors.