The study ex-ray the effectiveness of WhatsApp as a collaborative tool for learning among undergraduate students in the University of Uyo, Akwa Ibom State. The study was guided by two objectives of the study, two research questions and two hypotheses. The population of the study comprises of all the 400-level science education students in the faculty of education, University of Uyo, while the sample size of the study was sixty (60) science education students. A quasi-experimental design was used for the study. Mean and the standard deviation was used in addressing the research questions while Z-test and t-test were used in testing the null hypotheses. The findings reveal a significant difference in the retention level of students taught with WhatsApp application and those taught using the conventional approach of teaching, also that there is no significant difference between male and female students who use WhatsApp for learning. Conclusion and recommendations were also made.