This study aims to find the influence of the factors of capital structure and profitability of top five public sector banks during the period from 2012 to 2016. The study was based on secondary data. These data were taken from “Performance Highlights of Public Sector Banks”. Regression analysis was used to find the influencing the factors of capital structure and profitability. From the analysis debt-equity ratio was more influenced on the profitability of public sector banks and capital adequacy ratio has less influenced by profitability. There is no significant influencing among the factors of capital structure and profitability of public sector banks.