This study was designed to investigate the effect of constructivist 7-E learning approach on academic achievement of senior secondary school chemistry students in Rivers State. The design of the study was quasi-experiment of pre-test and post-test control group. The population consist of one hundred senior secondary school two students from two schools in Port Harcourt local government area of Rivers state. The research instrument, Chemistry achievement test (CAT) was used to collect data for both pre-test and post-test. Mean and standard deviation were used to answer the research questions while analysis of covariance [ANCOVA] was used to test hypotheses at alpha level of 0.05. The findings revealed that students taught with constructivist approach achieved better than those taught with traditional teaching method.