This article is on refocusing public universities for youths’ skill acquisition toward combating unemployment challenges in Nigeria. Government has a responsibility to be sensitive to issues that may constitute threats to peace and national security. Absence of peace in a polity is invitation to anarchy. Raising armies of unskilled youths that are not employable is an indirect way of inviting restiveness, joining religious extremist groups, stealing, pilfering, armed robbery, kidnapping, militancy, cultism, etc. Skill acquisition on the other hand referred to as entrepreneurship education, is not about generating ideas or making money but having entrepreneurial thinking, attitudes or mindset that emancipate one from not just being a burden to the society, but contributes toward its development and survival, offers students the transversal skills which increase their employability rate and most importantly imbue them with the capacity for imaginative thinking, is the answer to unemployment challenges that our university system must be refocused to address. The concepts of refocusing public universities, unemployment challenges, justification for refocusing public universities, entrepreneurship education (skill acquisition), Managing entrepreneurship education in a refocused university system were discussed. The article equally featured resources and strategies required in refocusing university system conclusion and recommendations on refocusing public universities for youths’ skill acquisition toward combating unemployment challenges in Nigeria.